Epigenetic Remodelling of Neonatal and Maternal Monocytes in Pregnancy Epigenetic Remodelling of Neonatal and Maternal Monocytes in Pregnancy

Long-term histone lactylation connects metabolic and epigenetic rewiring in innate immune memory

A Ziogas, B Novakovic, L Ventriglia, N Galang, KA Tran, W Li, V Matzaraki, N van Unen, T Schlüter, AV Ferreira, SJCFM Moorlag, VACM Koeken, M Moyo, X Li, MPA Baltissen, JHA Martens, Y Li, M Divangahi, LAB Joosten, MM Mhlanga

2025-05-29

Trained immunity, a de facto innate immune memory characterized by enhanced responsiveness to future challenges, is underpinned by..

A Composite Epigenetic Biomarker of FOXP3/TIGIT Correlates With Regulatory T Cell Numbers in Cord Blood and Is Associated With Subsequent Food Allergy

VH Nguyen, M O'Hely, F Collier, L Sominsky, P Dhar, J Molloy, AL Ponsonby, MLK Tang, P Sly, R Saffery, B Novakovic, P Vuillermin, L Harrison, T Mansell, D Burgner, S Ranganathan

2025-01-01

Background: Flow cytometry studies have reported an association between lower regulatory T cells (Treg) in cord blood and subseque..

Downregulation of type I interferon signalling pathway by urate in primary human PBMCs

M Badii, V Nica, AR Straton, B Kischkel, O Gaal, G Cabău, V Klück, I Hotea, LAB Joosten, IV Pop, RA Popp, S Rednic, C Pamfil, TO Crişan, M Farcaş†, DH Marginean, L Peca, AM Mirea, D Colcear, MS Pop

2025-01-01

Type I interferons (IFN1s) mediate innate responses to microbial stimuli and regulate interleukin (IL)-1 and IL-1 receptor antagon..

Effect of Bacille Calmette–Guérin vaccination on immune responses to SARS-CoV-2 and COVID-19 vaccination

NL Messina, S Germano, AW Chung, CE van de Sandt, NE Stevens, LF Allen, R Bonnici, J Croda, C Counoupas, B Grubor-Bauk, ER Haycroft, K Kedzierska, E McDonald, R McElroy, MG Netea, B Novakovic, KP Perrett, LF Pittet, RA Purcell, K Subbarao

2025-01-01

Objectives: Bacille Calmette–Guérin (BCG) vaccination has off-target effects on disease risk for unrelated infections and immune r..

Tracking Epigenetic Biomarkers of Health and Aging During the Initial Year of Gender-Affirming Hormone Therapy

K Mozhui, BA Henriksen, LA Bell, I Bretherton, AS Cheung, B Novakovic

2025-01-01

Gender-affirming hormone therapy (GAHT) is a necessary treatment for many transgender people, and there is a critical need to furt..

Impact of Distinct Antiandrogen Exposures on the Plasma Metabolome in Feminizing Gender-affirming Hormone Therapy

R Shepherd, LM Angus, T Mansell, B Arman, BW Kim, K Lange, D Burgner, JA Kerr, K Pang, JD Zajac, R Saffery, A Cheung, B Novakovic

2024-11-01

Context: The plasma metabolome is a functional readout of metabolic activity and is associated with phenotypes exhibiting sexual d..

Epigenomic variability is associated with age-specific naïve CD4 T cell response to activation in infants and adolescents

S Imran, MR Neeland, DJ Martino, S Peng, J Koplin, SC Dharmage, MLK Tang, S Sawyer, T Dang, V McWilliam, RL Peters, S Prescott, KP Perrett, B Novakovic, R Saffery

2023-05-01

Childhood is a critical period of immune development. During this time, naïve CD4 (nCD4) T cells undergo programmed cell different..

Immuno-epigenomic analysis identifies attenuated interferon responses in naïve CD4 T cells of adolescents with peanut and multi-food allergy

S Imran, MR Neeland, S Peng, A Vlahos, D Martino, SC Dharmage, MLK Tang, S Sawyer, TD Dang, V McWilliam, RL Peters, JJ Koplin, KP Perrett, B Novakovic, R Saffery

2022-11-01

Background: IgE-mediated food allergies have been linked to suboptimal naïve CD4 T (nCD4T) cell activation in infancy, underlined ..

Trained innate immunity, long-lasting epigenetic modulation, and skewed myelopoiesis by heme

E Jentho, C Ruiz-Moreno, B Novakovic, I Kourtzelis, WL Megchelenbrink, R Martins, T Chavakis, MP Soares, L Kalafati, J Guerra, F Roestel, P Bohm, M Godmann, T Grinenko, A Eugster, M Beretta, LAB Joosten, MG Netea, M Bauer, HG Stunnenberg

2021-10-19

Trained immunity defines long-lasting adaptations of innate immunity based on transcriptional and epigenetic modifications of myel..

Association of medically assisted reproduction with offspring cord blood DNA methylation across cohorts

D Caramaschi, J Jungius, CM Page, B Novakovic, R Saffery, J Halliday, S Lewis, MC Magnus, SJ London, SE Håberg, CL Relton, DA Lawlor, HR Elliott

2021-08-01

STUDY QUESTION: Is cord blood DNA methylation associated with having been conceived by medically assisted reproduction? SUMMARY AN..

Sexual Dimorphism in Innate Immunity: The Role of Sex Hormones and Epigenetics

R Shepherd, AS Cheung, K Pang, R Saffery, B Novakovic

2021-01-21

Sexual dimorphism refers to differences between biological sexes that extend beyond sexual characteristics. In humans, sexual dimo..

Epigenetic programming underpins B-cell dysfunction in peanut and multi-food allergy

S Imran, MR Neeland, J Koplin, S Dharmage, MLK Tang, S Sawyer, T Dang, V McWilliam, R Peters, KP Perrett, B Novakovic, R Saffery

2021-01-01

Objective: Rates of IgE-mediated food allergy (FA) have increased over the last few decades, and mounting evidence implicates disr..

Lysine methyltransferase G9a is an important modulator of trained immunity

VP Mourits, JH van Puffelen, B Novakovic, M Bruno, AV Ferreira, RJW Arts, L Groh, TO Crișan, J Zwaag, E Jentho, M Kox, P Pickkers, FL van de Veerdonk, S Weis, E Oosterwijk, SH Vermeulen, MG Netea, LAB Joosten

2021-01-01

Objectives: Histone methyltransferase G9a, also known as Euchromatic Histone Lysine Methyltransferase 2 (EHMT2), mediates H3K9 met..

A Potential Role for Epigenetically Mediated Trained Immunity in Food Allergy

S Imran, MR Neeland, R Shepherd, N Messina, KP Perrett, MG Netea, N Curtis, R Saffery, B Novakovic

2020-06-26

Immunology; Systems Biology; Omics